The reputation for holiness of Lautein, a monk from Autun who founded a small monastery here in the 6th century, soon attracted many followers. Later, his shrine attracted many pilgrims. Initially granted to Gigny, this small rural monastic establishment, occupied by a prior and two monks, then depended on Baume-les-Messieurs whose abbots, lords of Saint-Lothain, resided in the abbey house near the church. The priory was abolished in 1770 and the buildings were sold in 1791. There are still some fine 15th century remains in the village.
The Romanesque church is the only vestige of the 11th century occupation. Its crypt, with its original vaulting, contains three sarcophagi, including that of Saint Lothain. The present bell tower-porch was built in 1716.
The church houses a collection of very fine sculptures from the 15th, 16th and 17th centuries.